Buy Generic Levaquin (Levofloxacin)

How to buy Levofloxacin 500 mg?

For buying this antibiotic in any available dosage, you should follow the instruction for use. First of all, choose the right combination: dosage and quantity. It may differ (quantity). Our online service is a kind of wholesale store. The more you buy the more you save. If you are on antibiotics frequantly you may buy more pills for two courses, for example. We offer drugs with a long shelf-life.

After choosing the right product, you are to add it to the shopping cart. Sometimes, we offer discounts which are calculated automatically. The next step is to proceed to the checkout. We do not ask to send us a prescription but insist on visiting a doctor before making an order. Having submitted an order, wait for it for a stated period of time.

We offer international delivery. That’s why the only difference will lie in the term required for delivery. We offer regular delivery bringing parcels within 14-21 business days. Express delivery will take 5-9 business days. The fee is fixed and doesn’t depend on destination.

What is generic name of Levaquin?

Generic name of this antibiotic is its main component name – Levofloxacin. Generic analog has no difference with branded one. It will provide the same therapeutic effect as well as brand-name provides. The dosage is the same available on the pharmaceutical market. We remind you that generic is an absolute analog of a brand-name drug in therapeutic effect, bioequivalence, clearance, side effects, contraindications, and possible combinability with other medications from different drug groups. When buying Levaquin you buy its generic from our website.

What is Levaquin?

Levaquin is a broad-spectrum antimicrobial agent. The drug class: fluoroquinolone. It has bactericidal properties. It blocks DNA gyrase (topoisomerase II) and topoisomerase IV, disrupts supercoiling and cross-linking of DNA breaks, inhibits DNA synthesis, and causes deep morphological changes in the cytoplasm, cell wall and membranes.

It is active against:

• Enterococcus faecalis;
• Staphylococcus aureus;
• Staphylococcus epidermidis;
• Streptococcus pneumoniae;
• Streptococcus pyogenes and Streptococcus agalactiae;
• Viridans group streptococci;
• Enterobacter cloacae;
• Enterobacter aerogenes;
• Enterobacter agglomerans;
• Enterobacter sakazakii;
• Escherichia coli;
• Haemophilus influenzae;
• Haemophilus parainfluenzae;
• Klebsiella pneumoniae;
• Klebsiella oxytoca;
• Legionella pneumoniae;
• Moraxella catarrhalis;
• Proteus mirabilis;
• Pseudomonas aeruginosa;
• Pseudomonas fluorescens;
• Chlamydia pneumoniae;
• Mycoplasma pneumoniae;
• Acinetobacter anitratus;
• Acinetobacter baumannii;
• Acinetobacter calcoaceticus;
• Bordetella pertussis;
• Citrobacter diversus;
• Citrobacter freundii;
• Morganella morganii;
• Proteus vulgaris;
• Providencia rettgeri;
• Providencia stuartii;
• Serratia marcescens;
• Clostridium perfringens.

What is Levofloxacin used for?

Levofloxacin-sensitive bacterial infections in adults are:

• acute sinusitis;
• exacerbation of chronic bronchitis;
• community-acquired pneumonia;
• uncomplicated urinary tract infections;
• complicated urinary tract infections (including pyelonephritis);
• chronic bacterial prostatitis;
• infections of the skin and soft tissues;
• the complex treatment of drug-resistant forms of tuberculosis;
• prevention and treatment of anthrax with airborne infection.

More details about this antibtiotic are given in this video:

Dosage

Sinusitis (inflammation of the sinuses)	500 mg once a day – 10-14 days
Exacerbation of chronic bronchitis	250 mg or 500 mg once a day for 7-10 days
Levaquin dosage for community-acquired pneumonia	500 mg 1-2 times a day – 7-14 days
Uncomplicated urinary tract infections	250 mg once a day – 3 days
Prostatitis	500 mg once a day for 28 days
Complicated urinary tract infections, including pyelonephritis	250 mg once a day – 7-10 days
Skin and soft tissue infections	250 mg once a day or 500 mg 1-2 times a day – 7-14 days
Septicemia/bacteremia	250 mg or 500 mg 1-2 times a day – 10-14 days
Intraabdominal infection	250 mg or 500 mg once a day – 7-14 days (in combination with antibacterial drugs acting on anaerobic flora)

Resistance

Levofloxacin resistance develops as a result of a phased process of mutations in genes encoding both type II topoisomerases: DNA gyrase and topoisomerase IV. Other resistance mechanisms, such as the mechanism of influence on the penetration barriers of a microbial cell (the mechanism characteristic of Pseudomonas aeruginosa) and the mechanism of efflux (active removal of an antimicrobial agent from a microbial cell), can also reduce the sensitivity of microorganisms to levofloxacin.

Due to the peculiarities of the mechanism of levofloxacin action, usually there is no cross-resistance between levofloxacin and other antimicrobial agents.

Contraindications

• Hypersensitivity to levofloxacin, other fluoroquinolones or any other component of the drug;
• Epilepsy;
• Pseudoparalytic myasthenia gravis;
• Tendon lesions with previous treatment with quinolones;
• Impaired renal function (with CC less than 20 ml / min);
• Being on hemodialysis;
• Pregnancy;
• Period of breastfeeding;
• Children and adolescents under 18 years of age (due to incomplete growth of the skeleton, since the risk of damage to the cartilaginous growth);
• Lactase deficiency, lactose intolerance or glucose-galactose malabsorption.

Side effects

Frequancy	Side effects appearance
Often:	у 1-10 patients out of 100
Sometimes:	less than 1 patients out of 100
Rarely:	less than 1 patients out of 1 000
Very are:	less than 1 patients out of 10 000
Individual cases	less than 0,01%

Data obtained in clinical trials and in post-marketing use of this antibiotic

• Cardiovascular system: rarely – sinus tachycardia, palpitations; the frequency is unknown (post-marketing data) – lengthening of the QT interval, ventricular rhythm disturbances, ventricular tachycardia, ventricular tachycardia of the Pirouette type, which can lead to cardiac arrest.
• Blood and lymphatic system: infrequently – leukopenia (decrease in the number of leukocytes in peripheral blood), eosinophilia (increase in the number of eosinophils in peripheral blood); rarely, neutropenia (a decrease in the number of neutrophils in the peripheral blood), thrombocytopenia (a decrease in the number of platelets in the peripheral blood); the frequency is unknown (post-marketing data) – pancytopenia (decrease in the number of all formed elements in peripheral blood), agranulocytosis (absence or sharp decrease in the number of granulocytes in peripheral blood), hemolytic anemia.
• Nervous system: often – headache, dizziness; infrequently – drowsiness, tremor, dysgeusia (perversion of taste); rarely – paresthesia, convulsions; the frequency is unknown (post-marketing data) – peripheral sensory neuropathy, peripheral sensory-motor neuropathy, dyskinesia, extrapyramidal disorders, agovesia (loss of taste), parosmia (disorder of sensation of smell, especially subjective smell, objectively absent), including loss of smell, fainting, benign intracranial hypertension.
• The organ of vision: rarely – visual impairment, such as blurry visible image; frequency unknown (post-marketing data) – transient loss of vision, uveitis.
• Hearing impairment and labyrinthine disorders: infrequently – vertigo (feeling of deviation or spinning or of one’s own body or surrounding objects); rarely – ringing in the ears; frequency unknown (post-marketing data) – hearing loss.
• Respiratory system, chest and mediastinal organs: infrequently – shortness of breath; the frequency is unknown (post-marketing data) – bronchospasm, allergic pneumonitis.
• Gastrointestinal tract: often – diarrhea, vomiting, nausea; infrequently – abdominal pain, dyspepsia, flatulence, constipation; the frequency is unknown (post-marketing data) – hemorrhagic diarrhea, which in very rare cases can be a sign of enterocolitis, including pseudomembranous colitis, pancreatitis.
• Kidneys and urinary tract: infrequently – increased serum creatinine concentration; rarely, acute renal failure (for example, due to the development of interstitial nephritis).
• Skin and subcutaneous tissues*: infrequently – rash, itching, urticaria, hyperhidrosis; the frequency is unknown (post-marketing data) – toxic epidermal necrolysis, Stevens-Johnson syndrome, exudative erythema multiforme, photosensitization reactions (hypersensitivity to solar and ultraviolet radiation, leukocytoclastic vasculitis, stomatitis.
• Musculoskeletal system and connective tissue*: infrequently – arthralgia, myalgia; rarely – tendon damage, including tendonitis (for example, Achilles tendon), muscle weakness, which can be especially dangerous in patients with pseudoparalytic myasthenia gravis (myasthenia gravis); the frequency is unknown (post-marketing data) – rhabdomyolysis, tendon rupture (for example, Achilles tendon.
• Metabolic and nutritional disorders: infrequently – anorexia; rarely – hypoglycemia, especially in patients with diabetes mellitus (possible signs of hypoglycemia: “wolf” appetite, nervousness, perspiration, trembling); the frequency is unknown – hyperglycemia, hypoglycemic coma.
• Infectious and parasitic diseases: infrequently – fungal infections, development of pathogenic microorganisms’ resistance.
• Blood vessels: rarely – a decrease in blood pressure. General disorders: infrequently – asthenia; rarely – pyrexia (fever); frequency unknown – pain (including back, chest, and limb pain).
• Immune system: rarely – angioedema; the frequency is unknown (post-marketing data) – anaphylactic shock.

* Reactions from the skin and mucous membranes can sometimes develop even after taking the first dose of the drug.

* This side effect can be observed within 48 hours after the start of treatment and can be bilateral in nature, ligament rupture, rupture muscle arthritis.

Interaction with other drugs

Levaquin 500 mg increases T1 / 2 of cyclosporine. The effect of levofloxacin (the main component of this antibiotic) is reduced by drugs that inhibit intestinal motility, sucralfate, magnesium and aluminum-containing antacids and iron salts (it is necessary to take a at least 2 hours-break between application).

The concamitant use of NSAIDs – theophylline increases convulsive readiness, GCS – increase the risk of tendon rupture. Cimetidine and drugs that block tubular secretion slow down the excretion of levofloxacin. The solution of levofloxacin for iv administration is compatible with 0.9% sodium chloride solution, 5% dextrose solution, 2.5% Ringer’s solution with dextrose, combined solutions for parenteral nutrition (amino acids, carbohydrates, electrolytes). A solution of levofloxacin for iv administration cannot be mixed with heparin and solutions containing an alkaline reaction.

How long does it take for Levaquin to get out of your system?

Levaquin is rapidly and almost completely absorbed after oral administration. Meals provide little effect on the speed and completeness of absorption. The bioavailability of levofloxacin 500 mg after oral administration is almost 100%. After taking a single dose of 500 mg of levofloxacin, the maximum concentration is 5.2-6.9 μg/ml, the time to reach the maximum concentration is 1.3 hours, the half-life is 6-8 hours.

Binding with plasma proteins – 30-40%. It penetrates well into organs and tissues: lungs, mucous membrane of the bronchi, sputum, organs of the genitourinary system, bone tissue, cerebrospinal fluid, prostate gland, polymorphonuclear leukocytes, alveolar macrophages.

A small portion is oxidized and/or deacetylated in the liver. It is excreted mainly by the kidneys by glomerular filtration and tubular secretion. After oral administration, approximately 87% of the dose taken is excreted unchanged in the urine within 48 hours, less than 4% with feces within 72 hours.

Levofloxacin and alcohol – worth or not?

First of all, all types of antibiotics adversely affect the liver. It is this organ that is responsible for cleansing the body of toxic and harmful substances. The system starts to work with increased load and in case of alcohol consumption. This means that an alcoholic cocktail in combination with levoflaxacin has a double side effect on the liver.

In addition, alcohol in any quantity provokes side effects of the antibiotic. Since the antibiotic affects the body widely, the negative consequences can manifest itself in several symptoms at once, for example, the patient may feel sick, pressure may drop, and erythema is formed. In such situations, it is necessary to urgently contact a medical institution, since without the help of a specialist you can not overcome this disorder. In this way, a person is not treated, but is experimenting with his/her health.

It is worth noting that these warnings relate not only to drinks with high strength, but also to various low-alcohol drinks. Therefore, do not think that when drinking beer during the period of antibiotic treatment, you will not reduce the drug effectiveness. Since in most cases, it is taken in large volumes, it also causes negative consequences. Keep in mind that it is impossible to guess which symbiosis of substances will occur. It is best to exclude alcohol for the duration of the therapeutic course. This approach will not only save you from the disease faster, but also eliminate the risk of complications.