Generic Levaquin (Levofloxacin) is an antibacterial drug of the fluoroquinolone group. Levofloxacin is the levorotatory isomer of ofloxacin. It blocks the enzymes DNA gyrase (topoisomerase II) and topoisomerase IV. It disrupts supercoiling and cross-linking of DNA breaks. It inhibits DNA synthesis, and causes deep morphological changes in the cytoplasm, cell wall and bacterial membrane.Visit Online Pharmacy
For buying this antibiotic in any available dosage, you should follow the instruction for use. First of all, choose the right combination: dosage and quantity. It may differ (quantity). Our online service is a kind of wholesale store. The more you buy the more you save. If you are on antibiotics frequantly you may buy more pills for two courses, for example. We offer drugs with a long shelf-life.
After choosing the right product, you are to add it to the shopping cart. Sometimes, we offer discounts which are calculated automatically. The next step is to proceed to the checkout. We do not ask to send us a prescription but insist on visiting a doctor before making an order. Having submitted an order, wait for it for a stated period of time.
We offer international delivery. That’s why the only difference will lie in the term required for delivery. We offer regular delivery bringing parcels within 14-21 business days. Express delivery will take 5-9 business days. The fee is fixed and doesn’t depend on destination.
Generic name of this antibiotic is its main component name – Levofloxacin. Generic analog has no difference with branded one. It will provide the same therapeutic effect as well as brand-name provides. The dosage is the same available on the pharmaceutical market. We remind you that generic is an absolute analog of a brand-name drug in therapeutic effect, bioequivalence, clearance, side effects, contraindications, and possible combinability with other medications from different drug groups. When buying Levaquin you buy its generic from our website.
Levaquin is a broad-spectrum antimicrobial agent. The drug class: fluoroquinolone. It has bactericidal properties. It blocks DNA gyrase (topoisomerase II) and topoisomerase IV, disrupts supercoiling and cross-linking of DNA breaks, inhibits DNA synthesis, and causes deep morphological changes in the cytoplasm, cell wall and membranes.
It is active against:
Levofloxacin-sensitive bacterial infections in adults are:
More details about this antibtiotic are given in this video:
|Sinusitis (inflammation of the sinuses)||500 mg once a day – 10-14 days|
|Exacerbation of chronic bronchitis||250 mg or 500 mg once a day for 7-10 days|
|Levaquin dosage for community-acquired pneumonia||500 mg 1-2 times a day – 7-14 days|
|Uncomplicated urinary tract infections||250 mg once a day – 3 days|
|Prostatitis||500 mg once a day for 28 days|
|Complicated urinary tract infections, including pyelonephritis||250 mg once a day – 7-10 days|
|Skin and soft tissue infections||250 mg once a day or 500 mg 1-2 times a day – 7-14 days|
|Septicemia/bacteremia||250 mg or 500 mg 1-2 times a day – 10-14 days|
|Intraabdominal infection||250 mg or 500 mg once a day – 7-14 days (in combination with antibacterial drugs acting on anaerobic flora)|
Levofloxacin resistance develops as a result of a phased process of mutations in genes encoding both type II topoisomerases: DNA gyrase and topoisomerase IV. Other resistance mechanisms, such as the mechanism of influence on the penetration barriers of a microbial cell (the mechanism characteristic of Pseudomonas aeruginosa) and the mechanism of efflux (active removal of an antimicrobial agent from a microbial cell), can also reduce the sensitivity of microorganisms to levofloxacin.
Due to the peculiarities of the mechanism of levofloxacin action, usually there is no cross-resistance between levofloxacin and other antimicrobial agents.
|Frequancy||Side effects appearance|
|Often:||у 1-10 patients out of 100|
|Sometimes:||less than 1 patients out of 100|
|Rarely:||less than 1 patients out of 1 000|
|Very are:||less than 1 patients out of 10 000|
|Individual cases||less than 0,01%|
* Reactions from the skin and mucous membranes can sometimes develop even after taking the first dose of the drug.
* This side effect can be observed within 48 hours after the start of treatment and can be bilateral in nature, ligament rupture, rupture muscle arthritis.
Levaquin 500 mg increases T1 / 2 of cyclosporine. The effect of levofloxacin (the main component of this antibiotic) is reduced by drugs that inhibit intestinal motility, sucralfate, magnesium and aluminum-containing antacids and iron salts (it is necessary to take a at least 2 hours-break between application).
The concamitant use of NSAIDs – theophylline increases convulsive readiness, GCS – increase the risk of tendon rupture. Cimetidine and drugs that block tubular secretion slow down the excretion of levofloxacin. The solution of levofloxacin for iv administration is compatible with 0.9% sodium chloride solution, 5% dextrose solution, 2.5% Ringer’s solution with dextrose, combined solutions for parenteral nutrition (amino acids, carbohydrates, electrolytes). A solution of levofloxacin for iv administration cannot be mixed with heparin and solutions containing an alkaline reaction.
Levaquin is rapidly and almost completely absorbed after oral administration. Meals provide little effect on the speed and completeness of absorption. The bioavailability of levofloxacin 500 mg after oral administration is almost 100%. After taking a single dose of 500 mg of levofloxacin, the maximum concentration is 5.2-6.9 μg/ml, the time to reach the maximum concentration is 1.3 hours, the half-life is 6-8 hours.
Binding with plasma proteins – 30-40%. It penetrates well into organs and tissues: lungs, mucous membrane of the bronchi, sputum, organs of the genitourinary system, bone tissue, cerebrospinal fluid, prostate gland, polymorphonuclear leukocytes, alveolar macrophages.
A small portion is oxidized and/or deacetylated in the liver. It is excreted mainly by the kidneys by glomerular filtration and tubular secretion. After oral administration, approximately 87% of the dose taken is excreted unchanged in the urine within 48 hours, less than 4% with feces within 72 hours.
First of all, all types of antibiotics adversely affect the liver. It is this organ that is responsible for cleansing the body of toxic and harmful substances. The system starts to work with increased load and in case of alcohol consumption. This means that an alcoholic cocktail in combination with levoflaxacin has a double side effect on the liver.
In addition, alcohol in any quantity provokes side effects of the antibiotic. Since the antibiotic affects the body widely, the negative consequences can manifest itself in several symptoms at once, for example, the patient may feel sick, pressure may drop, and erythema is formed. In such situations, it is necessary to urgently contact a medical institution, since without the help of a specialist you can not overcome this disorder. In this way, a person is not treated, but is experimenting with his/her health.
It is worth noting that these warnings relate not only to drinks with high strength, but also to various low-alcohol drinks. Therefore, do not think that when drinking beer during the period of antibiotic treatment, you will not reduce the drug effectiveness. Since in most cases, it is taken in large volumes, it also causes negative consequences. Keep in mind that it is impossible to guess which symbiosis of substances will occur. It is best to exclude alcohol for the duration of the therapeutic course. This approach will not only save you from the disease faster, but also eliminate the risk of complications.