Generic Macrobid (nitrofurantoin monohydrate) is an antibacterial agent. Its active ingredient is nitrofurantoin monohydrate. Macrobid drug class: nitrofurans. It destroys infectious agents and prevents their further reproduction. The main component of this drug inhibits the important biochemical processes of microbes, which leads to their death. This antibiotic blocks the production of toxins by pathogenic microbes, therefore, after taking this drug, the patient’s condition improves in the shortest possible time. The antibiotic activates the immune system, increasing the ability of white blood cells to phagocytosis.Visit Online Pharmacy
Every customer may buy Macrobid over the counter using our service. Our service is a way to buy antibacterial agents online without prescriptions. It is the drug that are effective in bacterial infections’ treatment and prevention. Every customer is able to buy this antibiotic online without prescription. We insist on visiting a healthcare physcian. The doctor will define the exact disease cause, dosage, possible side effects and contraindications. After this visit is completed, you may make an order online without sending us a prescription. Consequently, every customer may start treatment already after the order has been delivered.
The question whether Generic Macrobid is cheap or expensive is logic. We offer Generic Macrobid at attractive price because we reduce its rate due to several reasons:
Our price policy is worked out in such a way to become favorable and reasonable for both customers and our administration. We are not intent on cheating out customers. The only aim we have is to make shopping for antibiotics online much more affordable.
Macrobid of generic origin is a broad-spectrum antibacterial agent, bactericidal. The drug action is achieved due to the formation of highly reactive amino derivatives due to the reduction of the 5-nitro group with the participation of bacterial flavoproteins. Amino derivatives cause inactivation or alteration of bacterial ribosomes’ proteins, suppression of metabolism and synthesis of bacterial DNA, RNA, cell wall, as well as conformational changes in proteins and other macromolecules, which leads to the death of microorganisms. Nitrofurantoin inhibits aerobic metabolism in the bacterial cell.
The drug reaches therapeutic concentrations only in the urine, and therefore nitrofurantoin is used to treat urinary tract infections.
Nitrofurantoin is active against Esherichia coli, Klebsiella spp., Enterobacter spp., Proteus spp., Staphylococcus spp., Streptococcus spp., Shigella dysenteriae, Shigella flexneri, Shigella boydii, Shigella sonnei.
Nitrofurantoin (Macrobid) is used in inflammatory diseases of the urinary tract, including pyelonephritis, cystitis, which are caused by sensitive microorganisms.
The dose for adults is 50-100 mg, the frequency of use is 4 times/day. The daily dose for children is 5-7 mg/kg in 4 divided doses. The treatment duration lasts 7 days. If necessary, it is possible to continue treatment for another 3 days (only after urine is checked for sterility). With long-term maintenance treatment, the dose of nitrofurantoin should be reduced.
The risk of developing peripheral neuropathy is increased in patients with anemia, diabetes mellitus, electrolyte imbalance, vitamin B deficiency, severe renal failure.
Macrobid 100 mg should not be used to treat diseases of the cortical substance of the kidneys, purulent paranephritis and prostatitis. This antibiotic is not prescribed in combination with drugs that cause impaired renal function.
It is believed that the use of antibacterial agents of the nitrofuran group (Macrobid) in the last 30 days of pregnancy increases the risk of jaundice in newborns. While other antimicrobial agents do not have such an effect. Norwegian scientists conducted a population-based cohort study to determine the effect of nitrofurans and other antimicrobials, which are usually prescribed for urinary tract infections, on pregnancy and the development of perinatal complications.
The study was conducted on the basis of information from the National Birth Register of Norway and the National Database of Prescription Medicines. Scientists analyzed the data of 180,120 women who were pregnant between 2004 and 2008. It turned out that 5794 participants received nitrofurantoin at different stages of pregnancy – 1334 women in the first trimester and 979 patients in the last four weeks of pregnancy. Pregnancy outcomes in this group were compared with the control group, which included 20,643 women taking other antimicrobial drugs to treat urinary tract infections. Also, the data obtained were compared with a group of 130,889 women who were not prescribed antibacterial drugs at all during pregnancy.
Data analysis showed that the risk of giving birth to children with serious malformations due to the use of nitrofurantoin in the first trimester of pregnancy is not higher than when using other antibiotics, in particular beta-lactam – 31 out of 1334 (2.4%) versus 162 out of 5794 (2, 8%).
The use of nitrofurantoin (Macrobid) in the last 4 weeks of pregnancy resulted in the development of jaundice in 103 newborns from 959 or 10.8%, in the group of participants who did not receive antibiotics, this figure was 8.1%.
Thus, the results obtained contradict the data of American scientists from the Center for Disease Control and Prevention of the United States, which were published in the journal Pediatrics in 2009. They revealed a connection between the use of nitrofurantoin during pregnancy and the occurrence of congenital malformations in children.
These discrepancies may be due to differences in research design and different numbers of participants. American scientists based on a retrospective survey of a significantly smaller number of women about drugs, in particular antibiotics taken during pregnancy.
Thus, the use of Macrobid during pregnancy does not increase the risk of congenital malformations in newborns. However, when prescribing antibiotics during pregnancy, it is necessary to keep in mind that the benefits of treatment should exceed the possible risks.
Take this antibiotic orally after a meal, drink plenty of water (100-200 ml). Strictly follow the dosage pattern and treatment regimen throughout the therapy course, do not skip the dose and take it at regular intervals. If you miss a dose, take it as soon as possible; do not take if it is almost time for the next dose; do not double the dose. Withstand the therapy duration, especially with streptococcal infections.
The instructions for this drug do not indicate whether it can be combined with alcohol. However, in the presence of infectious and inflammatory diseases from the field of urology, drinking alcohol is highly not recommended. This can lead to unforeseen consequences and put the kidneys under heavy stress.
A medicine combined with alcohol can lead to hypotension, tachycardia, and shortness of breath. The presence of ethanol in the blood will adversely affect the patient’s state of health, so you can drink alcohol after successful treatment.
The presence of infection in the body indicates that the body is weakened, so alcohol together with Macrobid will lead to a large load. The medication blocks the metabolism of alcohol in the liver and at the stage of its conversion to acetic acid. As a result of this, ethanol reaches a higher concentration in the patient’s blood.
Moreover, alcohol has a potent diuretic effect, so it will begin to actively wash the medicine out of the body, preventing it from destroying the pathogenic microflora, which led to the inflammatory process. Therefore, the patient should protect himself from drinking alcohol until complete recovery.
The consequences of taking alcohol during infectious and inflammatory diseases of the genitourinary organs:
The use of alcohol leads to disease exacerbation and the appearance of acute symptoms. That is why it is important to abandon any alcoholic beverages at the time of therapy.
Macrobid has a bitter aftertaste, so you need to drink them whole without chewing. Take the drug with a plentiful amount of liquid. The average duration of treatment is 10 days. The exact dosage and duration of therapy should be prescribed by a doctor.
In order to prevent infection of the genitourinary system at the time of cystoscopy or catheterization, Macrobid is taken 30 minutes before the procedure. If for some reason the dose was missed, the next one should be taken in the usual mode. Double dosage is prohibited.
Nitrofurantoin interactions should be considered before starting therapy. Consult your physician to get acquainted with the full list of interactions.