Buy Generic Macrobid Online Without Prescription

Can I buy Macrobid over the counter?

Every customer may buy Macrobid over the counter using our service. Our service is a way to buy antibacterial agents online without prescriptions. It is the drug that are effective in bacterial infections’ treatment and prevention. Every customer is able to buy this antibiotic online without prescription. We insist on visiting a healthcare physcian. The doctor will define the exact disease cause, dosage, possible side effects and contraindications. After this visit is completed, you may make an order online without sending us a prescription. Consequently, every customer may start treatment already after the order has been delivered.

How much is Generic Macrobid?

The question whether Generic Macrobid is cheap or expensive is logic. We offer Generic Macrobid at attractive price because we reduce its rate due to several reasons:

• the absence of additional expenses on renting the office, advertizing, and etc;
• generic assortment;
• direct cooperation with the manufacturers.

Our price policy is worked out in such a way to become favorable and reasonable for both customers and our administration. We are not intent on cheating out customers. The only aim we have is to make shopping for antibiotics online much more affordable.

What is Macrobid of generic origin?

Macrobid of generic origin is a broad-spectrum antibacterial agent, bactericidal. The drug action is achieved due to the formation of highly reactive amino derivatives due to the reduction of the 5-nitro group with the participation of bacterial flavoproteins. Amino derivatives cause inactivation or alteration of bacterial ribosomes’ proteins, suppression of metabolism and synthesis of bacterial DNA, RNA, cell wall, as well as conformational changes in proteins and other macromolecules, which leads to the death of microorganisms. Nitrofurantoin inhibits aerobic metabolism in the bacterial cell.

The drug reaches therapeutic concentrations only in the urine, and therefore nitrofurantoin is used to treat urinary tract infections.

Nitrofurantoin is active against Esherichia coli, Klebsiella spp., Enterobacter spp., Proteus spp., Staphylococcus spp., Streptococcus spp., Shigella dysenteriae, Shigella flexneri, Shigella boydii, Shigella sonnei.

What is Nitrofurantoin (Macrobid) used for?

Nitrofurantoin (Macrobid) is used in inflammatory diseases of the urinary tract, including pyelonephritis, cystitis, which are caused by sensitive microorganisms.

Macrobid for uti – dosage

The dose for adults is 50-100 mg, the frequency of use is 4 times/day. The daily dose for children is 5-7 mg/kg in 4 divided doses. The treatment duration lasts 7 days. If necessary, it is possible to continue treatment for another 3 days (only after urine is checked for sterility). With long-term maintenance treatment, the dose of nitrofurantoin should be reduced.

Side effects

• The respiratory system: chest pain, cough, shortness of breath, pulmonary infiltrates, eosinophilia, interstitial pneumonitis or fibrosis, decreased respiratory function, an attack of bronchial asthma in patients with a history of asthma.
• The digestive system: discomfort in the epigastrium, anorexia, nausea, vomiting; rarely – hepatitis, cholestatic jaundice, abdominal pain, diarrhea.
• The side of the central nervous system and peripheral nervous system: peripheral neuropathy, headache, nystagmus, dizziness, drowsiness.
• Hemopoietic system: leukopenia, granulocytopenia, agranulocytosis, thrombocytopenia, hemolytic anemia, megaloblastic anemia (these changes are reversible).
• Allergic reactions: urticaria, Quincke’s edema, pruritus, rash; very rarely – anaphylactic shock.
• Dermatological reactions: exfoliative dermatitis, erythema multiforme.
• Other: drug fever, arthralgia, flu-like symptoms, superinfection of the genitourinary tract, often caused by Pseudomonas aeruginosa, are possible.

Special instructions when taking Macrobid 100 mg

The risk of developing peripheral neuropathy is increased in patients with anemia, diabetes mellitus, electrolyte imbalance, vitamin B deficiency, severe renal failure.

Macrobid 100 mg should not be used to treat diseases of the cortical substance of the kidneys, purulent paranephritis and prostatitis. This antibiotic is not prescribed in combination with drugs that cause impaired renal function.

Interactions

• The simultaneous use of nalidixic acid and antacids containing magnesium trisilicate reduces the antibacterial effect of nitrofurantoin.
• Nitrofurantoin is incompatible with fluoroquinolones.
• With the simultaneous use of drugs that block tubular secretion, they reduce the antibacterial effect of nitrofurantoin (by reducing the concentration of nitrofurantoin in the urine) and increase its toxicity (increases the concentration in the blood).

Macrobid (nitrofurantoin) during pregnancy – the experts’ point of view

It is believed that the use of antibacterial agents of the nitrofuran group (Macrobid) in the last 30 days of pregnancy increases the risk of jaundice in newborns. While other antimicrobial agents do not have such an effect. Norwegian scientists conducted a population-based cohort study to determine the effect of nitrofurans and other antimicrobials, which are usually prescribed for urinary tract infections, on pregnancy and the development of perinatal complications.

The study was conducted on the basis of information from the National Birth Register of Norway and the National Database of Prescription Medicines. Scientists analyzed the data of 180,120 women who were pregnant between 2004 and 2008. It turned out that 5794 participants received nitrofurantoin at different stages of pregnancy – 1334 women in the first trimester and 979 patients in the last four weeks of pregnancy. Pregnancy outcomes in this group were compared with the control group, which included 20,643 women taking other antimicrobial drugs to treat urinary tract infections. Also, the data obtained were compared with a group of 130,889 women who were not prescribed antibacterial drugs at all during pregnancy.

Data analysis showed that the risk of giving birth to children with serious malformations due to the use of nitrofurantoin in the first trimester of pregnancy is not higher than when using other antibiotics, in particular beta-lactam – 31 out of 1334 (2.4%) versus 162 out of 5794 (2, 8%).

The use of nitrofurantoin (Macrobid) in the last 4 weeks of pregnancy resulted in the development of jaundice in 103 newborns from 959 or 10.8%, in the group of participants who did not receive antibiotics, this figure was 8.1%.

Thus, the results obtained contradict the data of American scientists from the Center for Disease Control and Prevention of the United States, which were published in the journal Pediatrics in 2009. They revealed a connection between the use of nitrofurantoin during pregnancy and the occurrence of congenital malformations in children.

These discrepancies may be due to differences in research design and different numbers of participants. American scientists based on a retrospective survey of a significantly smaller number of women about drugs, in particular antibiotics taken during pregnancy.

Thus, the use of Macrobid during pregnancy does not increase the risk of congenital malformations in newborns. However, when prescribing antibiotics during pregnancy, it is necessary to keep in mind that the benefits of treatment should exceed the possible risks.

Patient information

Take this antibiotic orally after a meal, drink plenty of water (100-200 ml). Strictly follow the dosage pattern and treatment regimen throughout the therapy course, do not skip the dose and take it at regular intervals. If you miss a dose, take it as soon as possible; do not take if it is almost time for the next dose; do not double the dose. Withstand the therapy duration, especially with streptococcal infections.

• Consult a doctor if improvement does not occur within a few days or new symptoms appear.
• Do not drink alcoholic beverages during furazolidone therapy and within 4 days after its withdrawal.
• During therapy with furazolidone, foods and drinks containing tyramine (cheese, beer, wine, beans, smoked foods) should not be consumed in large quantities.
• During treatment with furazolidone, one should not take drugs for the treatment of cough and colds without a doctor’s prescription.
• Nitrofurantoin and furazidine can color the urine in a rusty yellow or brownish color.

What threatens the combination of Macrobid with alcohol?

The instructions for this drug do not indicate whether it can be combined with alcohol. However, in the presence of infectious and inflammatory diseases from the field of urology, drinking alcohol is highly not recommended. This can lead to unforeseen consequences and put the kidneys under heavy stress.

A medicine combined with alcohol can lead to hypotension, tachycardia, and shortness of breath. The presence of ethanol in the blood will adversely affect the patient’s state of health, so you can drink alcohol after successful treatment.

The presence of infection in the body indicates that the body is weakened, so alcohol together with Macrobid will lead to a large load. The medication blocks the metabolism of alcohol in the liver and at the stage of its conversion to acetic acid. As a result of this, ethanol reaches a higher concentration in the patient’s blood.

Moreover, alcohol has a potent diuretic effect, so it will begin to actively wash the medicine out of the body, preventing it from destroying the pathogenic microflora, which led to the inflammatory process. Therefore, the patient should protect himself from drinking alcohol until complete recovery.

The consequences of taking alcohol during infectious and inflammatory diseases of the genitourinary organs:

• persistent itching;
• pain during urination;
• false urge to urinate;
• aches and burning.

The use of alcohol leads to disease exacerbation and the appearance of acute symptoms. That is why it is important to abandon any alcoholic beverages at the time of therapy.

For how long to take this antibiotic?

Macrobid has a bitter aftertaste, so you need to drink them whole without chewing. Take the drug with a plentiful amount of liquid. The average duration of treatment is 10 days. The exact dosage and duration of therapy should be prescribed by a doctor.

In order to prevent infection of the genitourinary system at the time of cystoscopy or catheterization, Macrobid is taken 30 minutes before the procedure. If for some reason the dose was missed, the next one should be taken in the usual mode. Double dosage is prohibited.

Nitrofurantoin interactions should be considered before starting therapy. Consult your physician to get acquainted with the full list of interactions.