Generic Bactrim (Trimethoprim / Sulfamethoxazole) Online

What is Bactrim?

This is antimicrobial synthetic agent with a wide spectrum of action. Drug class: sulfonamides. Sulfamethoxazole has a bacteriostatic effect, which is associated with inhibition of the PABA utilization process and disruption of the synthesis of dihydrofolate in bacterial cells. Trimethoprim inhibits an enzyme that is involved in folic acid metabolism, converting dihydrofolate to tetrahydrofolate. Thus, 2 consecutive stages of the biosynthesis of purines and, therefore, nucleic acids, which are necessary for the growth and reproduction of bacteria, are blocked. High concentrations are created in the tissues of the lungs, kidneys, prostate gland, cerebrospinal fluid, bile, and bones.

The drug is active against gram-positive bacteria: Staphylococcus spp. (including penicillinase producing strains), Streptococcus spp. (including Streptococcus pneumoniae), Corynebacterium diphtheriae; gram-negative bacteria: Neisseria gonorrhoeae, Escherichia coli, Shigella spp., Salmonella spp., Proteus spp., Enterobacter spp., Klebsiella spp., Yersinia spp., Vibrio cholerae, Haemophilus influenzae; anaerobic non-spore forming bacteria – Bacteroides spp.

It is also active against Chlamydia spp.

Pseudomonas aeruginosa, Treponema spp., Mycoplasma spp., Mycobacterium tuberculosis, as well as viruses and fungi are resistant to this antibiotic.

How much is Bactrim?

The cost of this medicine varies from pharmacy to pharmacy. Good news is that today there is an opportunity to find the best price offer as quickly as possible. You can search for drug prices online,compare them and purchase the best option. Your local drugstores will probably offer you to expensive branded versions of trimethoprim/sulfamethoxazole. But you can order cheaper generic antibiotic from an online pharmacy. Besides, such stores sell many medicines over the counter. For example, we offer you to buy Generic Bactrim online only for $0.42 per pill.

Can you buy Bactrim without a prescription?

If you purchase antibiotics in your local pharmacy, you will need a valid prescription from your health care provider. However, if you are sure that you need this very medication for your infection, you can buy Bactrim online without a prescription. However, it is important to choose a well-known and reliable pharmacy. We recommend that you check the store’s reputation by reading online pharmacy reviews that can be easily found on the net. However, before you order and use any antibiotic, we still recommend that you consult a health care specialist, even if you have already used this drug and it was effective. Self-medication can be dangerous.

Bactrim uses

The drug is used to treat diseases associated with sensitive pathogenic flora.

• ENT practice: laryngitis, ear infections, sinusitis;
• Respiratory tract: bronchiectasis, bronchitis (both acute and chronic form, and the need to prevent exacerbations), pleural empyema, pneumonia (treatment and prevention), lung abscess. He drug can be used for pneumonia associated with Pneumocystis carinii in people with AIDS;
• Dermatology: acne, pyoderma, tissue abscesses, boils, infection of wounds;
• Gastroenterology: diarrhea of bacterial origin, cholera (in combination with other means), shigellosis, paratyphoid, typhoid fever, gastroenteritis (associated with E. coli), cholangitis, cholecystitis;
• Urological practice: pyelitis, pyelonephritis, acute and chronic forms of cystitis, urethritis, epididymitis, prostatitis;
• Sexually transmitted diseases: gonorrhea, inguinal granuloma, venereal lymphogranuloma, mild chancre;
• Surgery and other infections: inflammation of the meninges, brain abscess, malaria, septicemia, whooping cough (combined with other means), toxoplasmosis, osteomyelitis (both chronic and acute form), brucellosis, South American blastomycosis.

Dosage and administration

Generic Bactrim is available in 2 doses: 400/80mg and 800/160mg.

The tablets are intended for oral administration, a break between taking each of the single doses is 12 hours. It is recommended that you adhere to the specified interval between doses as accurately as possible (this allows you to maintain therapeutic levels of antibacterial substances in the body).

Dosage is individual and depends on pathogenic flora, severity and dynamics of the disease, as well as age, weight and excretory function of the kidneys.

The average recommended single dose (single dose is taken twice a day): for patients over 12 years – 2 tablets; patients aged 6-12 years – 1 tablet; for patients aged 6 months-5 years – 1/2 tablet; for patients aged 2 months-6 months – 1/4 tablet.

The average duration of antibiotic therapy is 5-7 days. The course of antibacterial treatment should not be interrupted even if the clinical signs of the disease disappear. If you have to undergo longer treatment (up to 14 days), it is recommended to take 50% of the average dose starting from the 7th day of therapy.

In the acute form of brucellosis, the duration of treatment should be 3-4 weeks, with paratyphoid and typhoid – 1-3 months.

The functional activity of the kidneys, liver and hematopoietic system should be monitored if the treatment time is more than 14 consecutive days. When prescribing high (shock) doses, a plentiful water consumption is required (to prevent crystalluria).

Side effects

• Nervous system and sensory organs: aseptic meningitis, headache, cramps, peripheral neuritis, ataxia, vertigo, tinnitus, headache, hallucinations, depression, apathy, nervousness, weakness, fatigue, insomnia;
• Digestive tract: nausea, vomiting, diarrhea, abdominal pain, anorexia, cholestatic and necrotic hepatitis, increased serum levels of transaminases and bilirubin, pseudomembranous enterocolitis, pancreatitis, stomatitis, glossitis;
• Respiratory system: allergic cough and shortness of breath, lung infiltrates;
• Hematopoietic organs: agranulocytosis, aplastic anemia, thrombocytopenia, leukopenia, neutropenia, hemolytic anemia, megaloblastic anemia, hypoprothrombinemia, methemoglobinemia, eosinophilia;
• Urinary system: renal failure, interstitial nephritis, increased plasma creatinine, toxic nephropathy with oliguria and anuria;
• Allergic reactions: urticaria, rash, toxic epidermal necrolysis (Lyell’s syndrome), Stevens-Johnson syndrome, anaphylaxis, allergic myocarditis, erythema multiforme, exfoliative dermatitis, Quincke’s edema, drug fever, chills, Shenlein-Genoch disease, allergic reactions, serum, generalized skin rash, photosensitivity, itching, redness of the sclera; There are reports of periarteritis nodosa and systemic lupus erythematosus;
• Other: hyperkalemia, hyponatremia, arthralgia, myalgia, individual cases of rhabdomyolysis (mainly in AIDS patients).

Many users wonder how long side effects of Bactrim last. Well, in most cases, the adverse reactions are short-lasting and mild. If you have long-lasting side effects after taking this drug, consult your doctor.

Contraindications

Do not take Bactrim if you have any of the following conditions:

• damage to the liver parenchyma;
• severe renal dysfunction in the absence of the ability to control the concentration of sulfamethoxazole and trimethoprim in blood plasma;
• severe renal failure (CC <15 ml / min);
• severe blood diseases (aplastic anemia, B12-deficient anemia, agranulocytosis, leukopenia, megaloblastic anemia, anemia associated with folic acid deficiency);
• hyperbilirubinemia in children;
• glucose-6-phosphate dehydrogenase deficiency;
• pregnancy;
• lactation (breastfeeding);
• children under 2 years;
• concomitant use with dofetilide;
• hypersensitivity to sulfonamides and trimethoprim.

Drug interactions

Avoid taking Bactrim (trimethoprim / sulfamethoxazole) with any of the following drugs:

• anticoagulants;
• some sulfonylurea derivatives;
• methotrexate;
• butadione, indomethacin, naproxen, salicylates and some other NSAIDs;
• diuretics;
• chloridine;
• colestyramine;
• phenytoin;
• pyrimethamine;
• digoxin;
• tricyclic antidepressants;
• cyclosporine;
• ACE inhibitors;
• dofetilide.

Pregnancy, breastfeeding, fertility

The safety of Bactrim during pregnancy has not been established. The drug should not be used during pregnancy, especially in the first trimester, and in women of childbearing age who do not use contraceptives. The benefit / risk ratio should be carefully assessed, and if use during pregnancy is necessary, an adequate intake of folic acid by the woman must be ensured. Pregnant women using this antibiotic are recommended to take 5 mg of folic acid per day.

The drug interferes with folic acid metabolism and can cause a teratogenic effect if used in the first trimester of pregnancy. Animal studies have shown teratogenic effects typical of folic acid deficiency. Sulfonamide-containing agents should not be used at the end of pregnancy due to the risk of nuclear jaundice in newborns. The drug can cause methemoglobinemia, hemolysis, hemolytic anemia, jaundice in newborns, including nuclear jaundice when used in the third trimester before childbirth. The risk of nuclear jaundice is higher in infants with an increased risk of hyperbilirubinemia, such as premature, sick newborns, or with congenital deficiency of glucose-6-phosphate dehydrogenase.

Both substances sulfamethoxazole and trimethoprim can be excreted in breast milk in small amounts that are not dangerous for children, but the antibiotic should not be used in breastfeeding women because of the increased risk of hyperbilirubinemia in children, especially with congenital deficiency of glucose-6-phosphate dehydrogenase.

A number of experiments revealed the negative effect of trimethoprim on spermatogenesis in animals after its use for a month.

What happens if you take too much Bactrim?

• Symptoms of acute overdose: anorexia, nausea, vomiting, weakness, abdominal pain, dizziness, headache, drowsiness, confusion; pyrexia, hematuria and crystalluria;
• Treatment: gastric lavage, fluid injection, correction of electrolyte disturbances, hemodialysis (if necessary);
• Symptoms of chronic overdose: bone marrow depression (thrombocytopenia, leukopenia and / or megaloblastic anemia);
• Treatment and prevention: folic acid administration (5-15 mg daily).

Compatibility with alcohol

Some types of antibiotics are incompatible with alcohol. You should never not drink alcohol while taking Bactrim (sulfamethoxazole + trimethoprim).

Combining alcohol (even weak and in minimal quantities) and these pills can cause skin redness, vomiting and fainting.

The antibiotic can affect the metabolism of folic acid in bacteria. In rare cases, it can also affect the metabolism of folic acid in human cells. With a deficiency of folic acid in the body, the combination of alcohol and this antibiotic leads to its further decrease.

Warning and precautions

Patients with impaired renal function with Cl creatinine 15–25 ml / min require a dose reduction.

If a rash, cough, arthralgia, or other symptoms occur, you should stop taking this antibiotic immediately. Long-term administration is carried out with systematic monitoring of the cellular composition of peripheral blood, the functional state of the liver and kidneys. To prevent crystalluria, an abundant alkaline consumption is recommended (2-3 liters of fluid per day).

Excessive sun and UV exposure should be avoided. The risk of side effects is significantly higher in AIDS patients. Concomitant administration of folic acid to HIV-infected patients increases the likelihood of developing resistance to sulfonamides in Pneumocystis carinii strains.
It is not recommended to use Bactrim for tonsillitis and pharyngitis caused by beta-hemolytic group A streptococcus due to the widespread resistance of the strains.