Generic Bactrim is a combination of two antibiotics (sulfamethoxazole and trimethoprim) used to treat a wide variety of bacterial infections susceptible to this substance.Visit Online Pharmacy
This is antimicrobial synthetic agent with a wide spectrum of action. Drug class: sulfonamides. Sulfamethoxazole has a bacteriostatic effect, which is associated with inhibition of the PABA utilization process and disruption of the synthesis of dihydrofolate in bacterial cells. Trimethoprim inhibits an enzyme that is involved in folic acid metabolism, converting dihydrofolate to tetrahydrofolate. Thus, 2 consecutive stages of the biosynthesis of purines and, therefore, nucleic acids, which are necessary for the growth and reproduction of bacteria, are blocked. High concentrations are created in the tissues of the lungs, kidneys, prostate gland, cerebrospinal fluid, bile, and bones.
The drug is active against gram-positive bacteria: Staphylococcus spp. (including penicillinase producing strains), Streptococcus spp. (including Streptococcus pneumoniae), Corynebacterium diphtheriae; gram-negative bacteria: Neisseria gonorrhoeae, Escherichia coli, Shigella spp., Salmonella spp., Proteus spp., Enterobacter spp., Klebsiella spp., Yersinia spp., Vibrio cholerae, Haemophilus influenzae; anaerobic non-spore forming bacteria – Bacteroides spp.
It is also active against Chlamydia spp.
Pseudomonas aeruginosa, Treponema spp., Mycoplasma spp., Mycobacterium tuberculosis, as well as viruses and fungi are resistant to this antibiotic.
The cost of this medicine varies from pharmacy to pharmacy. Good news is that today there is an opportunity to find the best price offer as quickly as possible. You can search for drug prices online,compare them and purchase the best option. Your local drugstores will probably offer you to expensive branded versions of trimethoprim/sulfamethoxazole. But you can order cheaper generic antibiotic from an online pharmacy. Besides, such stores sell many medicines over the counter. For example, we offer you to buy Generic Bactrim online only for $0.42 per pill.
If you purchase antibiotics in your local pharmacy, you will need a valid prescription from your health care provider. However, if you are sure that you need this very medication for your infection, you can buy Bactrim online without a prescription. However, it is important to choose a well-known and reliable pharmacy. We recommend that you check the store’s reputation by reading online pharmacy reviews that can be easily found on the net. However, before you order and use any antibiotic, we still recommend that you consult a health care specialist, even if you have already used this drug and it was effective. Self-medication can be dangerous.
The drug is used to treat diseases associated with sensitive pathogenic flora.
Generic Bactrim is available in 2 doses: 400/80mg and 800/160mg.
The tablets are intended for oral administration, a break between taking each of the single doses is 12 hours. It is recommended that you adhere to the specified interval between doses as accurately as possible (this allows you to maintain therapeutic levels of antibacterial substances in the body).
Dosage is individual and depends on pathogenic flora, severity and dynamics of the disease, as well as age, weight and excretory function of the kidneys.
The average recommended single dose (single dose is taken twice a day): for patients over 12 years – 2 tablets; patients aged 6-12 years – 1 tablet; for patients aged 6 months-5 years – 1/2 tablet; for patients aged 2 months-6 months – 1/4 tablet.
The average duration of antibiotic therapy is 5-7 days. The course of antibacterial treatment should not be interrupted even if the clinical signs of the disease disappear. If you have to undergo longer treatment (up to 14 days), it is recommended to take 50% of the average dose starting from the 7th day of therapy.
In the acute form of brucellosis, the duration of treatment should be 3-4 weeks, with paratyphoid and typhoid – 1-3 months.
The functional activity of the kidneys, liver and hematopoietic system should be monitored if the treatment time is more than 14 consecutive days. When prescribing high (shock) doses, a plentiful water consumption is required (to prevent crystalluria).
Many users wonder how long side effects of Bactrim last. Well, in most cases, the adverse reactions are short-lasting and mild. If you have long-lasting side effects after taking this drug, consult your doctor.
Do not take Bactrim if you have any of the following conditions:
Avoid taking Bactrim (trimethoprim / sulfamethoxazole) with any of the following drugs:
The safety of Bactrim during pregnancy has not been established. The drug should not be used during pregnancy, especially in the first trimester, and in women of childbearing age who do not use contraceptives. The benefit / risk ratio should be carefully assessed, and if use during pregnancy is necessary, an adequate intake of folic acid by the woman must be ensured. Pregnant women using this antibiotic are recommended to take 5 mg of folic acid per day.
The drug interferes with folic acid metabolism and can cause a teratogenic effect if used in the first trimester of pregnancy. Animal studies have shown teratogenic effects typical of folic acid deficiency. Sulfonamide-containing agents should not be used at the end of pregnancy due to the risk of nuclear jaundice in newborns. The drug can cause methemoglobinemia, hemolysis, hemolytic anemia, jaundice in newborns, including nuclear jaundice when used in the third trimester before childbirth. The risk of nuclear jaundice is higher in infants with an increased risk of hyperbilirubinemia, such as premature, sick newborns, or with congenital deficiency of glucose-6-phosphate dehydrogenase.
Both substances sulfamethoxazole and trimethoprim can be excreted in breast milk in small amounts that are not dangerous for children, but the antibiotic should not be used in breastfeeding women because of the increased risk of hyperbilirubinemia in children, especially with congenital deficiency of glucose-6-phosphate dehydrogenase.
A number of experiments revealed the negative effect of trimethoprim on spermatogenesis in animals after its use for a month.
Some types of antibiotics are incompatible with alcohol. You should never not drink alcohol while taking Bactrim (sulfamethoxazole + trimethoprim).
Combining alcohol (even weak and in minimal quantities) and these pills can cause skin redness, vomiting and fainting.
The antibiotic can affect the metabolism of folic acid in bacteria. In rare cases, it can also affect the metabolism of folic acid in human cells. With a deficiency of folic acid in the body, the combination of alcohol and this antibiotic leads to its further decrease.
Patients with impaired renal function with Cl creatinine 15–25 ml / min require a dose reduction.
If a rash, cough, arthralgia, or other symptoms occur, you should stop taking this antibiotic immediately. Long-term administration is carried out with systematic monitoring of the cellular composition of peripheral blood, the functional state of the liver and kidneys. To prevent crystalluria, an abundant alkaline consumption is recommended (2-3 liters of fluid per day).
Excessive sun and UV exposure should be avoided. The risk of side effects is significantly higher in AIDS patients. Concomitant administration of folic acid to HIV-infected patients increases the likelihood of developing resistance to sulfonamides in Pneumocystis carinii strains.
It is not recommended to use Bactrim for tonsillitis and pharyngitis caused by beta-hemolytic group A streptococcus due to the widespread resistance of the strains.